This course teaches a mechanism-first framework for brain function and cognitive decline using cellular energy and oxidative stress regulation (“redox balance”) as the organizing lens. You will examine how brain-derived neurotrophic factor (BDNF) signaling can shift based on inflammation, metabolism, and protein processing, and how this connects to synaptic plasticity and neurodegenerative risk. The lessons also address glycation (“sugar damage”), membrane lipid biology, and vascular–brain interface concepts such as endothelial function, blood–brain barrier integrity, and glymphatic clearance. Throughout, the course supports clinicians in translating mechanistic science into clearer clinical reasoning, including how to think about selected biomarkers, imaging, and genetic risk scoring within a larger differential. This approach aims to inform individualized evaluation and longitudinal follow-up in complex neurocognitive and brain-performance-adjacent cases by helping clinicians identify plausible contributors to symptoms and monitor defined endpoints over time. It is designed for clinicians and advanced health professionals, as well as trainees and researchers, who want a structured, evidence-aware way to interpret emerging brain-health science without relying on one-size-fits-all explanations.

The course is delivered as recorded, long-form lessons that prioritize mechanism-first teaching and clinical interpretation. Concepts are reinforced through intermittent Q&A and case-based discussion to help learners connect pathways to evaluation and monitoring considerations.

• Over 10 hours of video content
• 2 modules
• 6 video lessons
• Downloadable learning guides