Cellular senescence basics for clearer inflammation patterns and more structured patient follow-up
For clinicians managing complex aging-related presentations
This course teaches a clinician-oriented framework for understanding cellular senescence—when cells stop dividing yet remain biologically active and can contribute to chronic inflammatory signaling. You will explore how upstream drivers such as mitochondrial energy stress, nutrient sensing, and changes in immune surveillance can shape senescence patterns across tissues, including the brain and gut–immune interface. The lessons also review what senescence markers and pathways can and cannot tell you, and why tissue context matters when discussing senolytics or senomodulators as conceptual levers. Throughout, the emphasis is on translating mechanistic knowledge into clearer clinical reasoning, with attention to uncertainty and real-world heterogeneity. That approach can help clinicians choose measurable endpoints and reassess over time, supporting individualized care planning for complex chronic and aging-related presentations. It is designed for clinicians, and may also be useful for researchers and advanced trainees who want a structured bridge between aging biology and clinical interpretation.
What's Included
The course is organized as a stepwise progression from core mechanisms of senescence to integrative clinical interpretation and monitoring concepts. It revisits key ideas across sessions to reinforce an upstream-to-downstream model you can use for longitudinal follow-up and reassessment.
- Over 5 hours of video content
- 2 modules
- 6 video lessons
- Downloadable learning guides
William Seeds, MD
Before establishing the SSRP Institute, Dr. Seeds served as a board-certified orthopedic surgeon and sports medicine specialist for nearly three decades, including Chief of Surgery, Orthopedic Residency Site Director, and Director of The Ohio Bone & Joint Institute for University Hospitals.
His significant contributions to sports medicine have been recognized at the NFL Hall of Fame. He has consulted for athletes across all major sports leagues, including the NFL, NHL, MLB, NBA, and even the performers on “Dancing with the Stars.”
Through his research at the SSRP Institute, Dr. Seeds continues to explore the cellular pathways and mechanisms that positively impact disease and dysfunction in the body as well as optimize physical performance.
Highlights of Mastermind 8
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